📌 COMPOSITION

• Each 1 ml oral drops contains: Hyoscyamine sulfate 0.125 mg.
• Each 5 ml syrup contains: Hyoscyamine sulfate 0.125 mg.

📌 DESCRIPTION

Spasmokid (Hyoscyamine sulfate) is an anticholinergic, antispasmodic alkaloid. It inhibits gastrointestinal propulsive motility, decreases gastric acid secretion, and controls excessive pharyngeal, tracheal and bronchial secretions. Hyoscyamine sulfate specifically inhibits the action of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscle that responds to acetylcholine but lacks cholinergic innervation. Hyoscyamine sulfate is absorbed completely by oral administration and distributed throughout the entire body, with a half‑life of 2-3.5 hours. The majority of it is excreted unchanged in the urine within 12 hours.

📌 INDICATIONS

• Infant and children's colic.
• To control gastric secretion, visceral spasm and hypermotility in cases associated with abdominal cramps.
• As adjunctive therapy in the treatment of irritable bowel syndrome and functional intestinal disorders, to reduce symptoms such as those seen in mild dysenteries and diverticulitis.
• It can be used in the therapy of poisoning by anticholinesterase agents.

📌 DOSAGE & ADMINISTRATION

• Infants (2.5-4 kg): 2-3 drops.
• Infants (5-7 kg): 4-5 drops.
• Infants (8-10 kg): 6 drops.
• Children (2-6 years): 0.25-0.5 ml.
• Children (6-12 years): 0.5-1 ml of drops or 2.5-5 ml of syrup.
• Adults: 1-2 ml of drops or 5-10 ml of syrup.

The dose can be repeated as needed, but not more than every 4 hours.

📌 RESTRICTIONS ON USE

Contraindications

• Hypersensitivity to hyoscyamine sulfate or any anticholinergic drugs.
• Glaucoma, obstructive uropathy, gastrointestinal obstructive disease, paralytic ileus, intestinal atony, unstable cardiovascular status in acute haemorrhage, severe ulcerative colitis, toxic megacolon and myasthenia gravis.

Precautions

• Autonomic neuropathy, hyperthyroidism.
• Coronary heart disease, congestive heart failure, cardiac arrhythmias, hypertension and renal diseases.
• Hiatal hernia associated with reflux oesophagitis.

Effects on ability to drive and use machines

Spasmokid may produce drowsiness or blurred vision; therefore, it should not be taken during driving or using machines.

Use in Pregnancy and Lactation

Should not be given during pregnancy or the lactating period.

📌 DRUG INTERACTIONS

Spasmokid interacts with other antimuscarinics, amantadine, haloperidol, phenothiazines, monoamine oxidase inhibitors, tricyclic antidepressants and antacids.

📌 SIDE EFFECTS

Dryness of the mouth, urinary hesitancy and retention, blurred vision, mydriasis with cycloplegia, transient bradycardia followed by tachycardia with palpitations, increased ocular tension, constipation, headache, drowsiness, nervousness, decreased sweating, allergic reactions and urticaria.

📌 OVERDOSAGE

In case of overdosage, anticholinergic symptoms such as urinary retention, dry mouth, redness of the skin, tachycardia and transient visual disturbances may occur. Treatment involves gastric lavage with medical charcoal, followed by magnesium sulphate (15%).

📌 STORAGE INSTRUCTIONS

Store below 30°C, protect from light.

📌 PHARMACEUTICAL FORMS

• Spasmokid Oral Drops: Bottle of 20 ml.
• Spasmokid Syrup: Bottle of 60 ml.